A team of U.S. researchers has unraveled the mechanism by which a bacterium commonly found in the intestinal flora can cause colon cancer.
In an article published by the British journal Nature, experts from the Johns Hopkins University in Baltimore (USA) argue that ETBF bacteria (enterotoxigenic bacteria fragilis) are able to colonize the intestine in mice and cause inflammation of the colon and tumor development.
To achieve this, ETBF using the cytokine interleukin 17 (IL-17) or IL-23, which amplifies the responses of the first, continues the review team led by Cynthia Sears.
The IL-17 is a type of pro-inflammatory cytokine secreted by several subtypes of activated T cells and influences, in addition to cancer, autoimmune disease development.
Discovered this association, the researchers say such an alliance would be enough to avoid blocking the formation of cancer, opening the door for research into new therapies to combat the disease.
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